Subha Madhavan, PhD
People
Faculty & Staff
Adil Alaoui, MS
Alfreda Walker, BA
Anas Belouali, MS
Brian Conkright, MS
Difei Wang, PhD
Kanchi Krishnamurthy, MS
Krithika Bhuvaneshwar, MS
Laura Sheahan, PhD
Lei Song, MS
Lizeida Feuillebois, BSBA
Maki Nishida, PhD
Michael Harris, MA
Peter McGarvey, PhD
Robert Matt Johnson, BS
Shruti Rao, MS
Simina Boca, PhD
Subha Madhavan, PhD
Varun Singh, MS
Victor Clarke, MS
Yuriy Gusev, PhD
ICBI Alumni
Institutional Leadership
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Subha Madhavan, PhD

Subha Madhavan, PhD - Director, Biomedical Informatics

Dr. Madhavan is the Director of Biomedical Informatics and Center Director.  She leads several informatics efforts including the Georgetown Database of Cancer a tool for both researchers and clinicians to realize the goals of personalized medicine at GU, and the NIH caBIG In Silico Research Center for Excellence.   She also directs the Informatics cores for NIH funded translational efforts. She is the PI on the Breast and Colon Cancer Family Registries data center that coordinates public health and epidemiology data across 12 sites in the US, Australia, and Canada. More recently, she has partnered with the FDA on the Center for Excellence in Regulatory Science program to develop evidence bases for pharmacogenomics and vaccine adverse event detection.  She is also involved in a whole genome data analysis project with the Inova Translational Medicine Institute.

Prior to joining Georgetown, Dr. Madhavan served as the Associate Director of Product and Program Management in the Life sciences informatics area at NCI’s Center for Biomedical Informatics and Information technology. Her work at NCI involved bridging the gap between bench and bedside by enabling researchers and physician scientists to use cutting edge biomedical informatics solutions to identify better therapies for cancer. At NCI she led a group of scientists, physicians and software engineers in building REMBRANDT (REpository for Molecular BRAin Neoplasia DaTa) – a database that hosts and interconnects clinical data points with various genomics datasets from large brain tumor clinical trials. This effort won the Service to America Award. While at NCI she also established the data coordination center for The Cancer Genome Atlas (TCGA), which managed and analyzed high dimensional genomic data of approximately 100 TB over a period of 3 years.

At Georgetown, she leads various informatics efforts including the caBIG In Silico Research Center for Excellence, and the Georgetown Database of Cancer. She also directs the Informatics cores for NIH funded translational efforts such as the Center for Cancer Systems Biology at Georgetown; and the Clinical Translational Science Award at Georgetown along with Howard University, the Washington Veteran’s Affairs Medical Center, and MedStar Health Research Institute. She is the PI on the Breast and Colon Cancer Family Registries data center that coordinates public health and epidemiology data across 12 sites in the US, Australia, and Canada. More recently, she has partnered with the FDA on the Center for Excellence in Regulatory Science program to develop evidence bases for pharmacogenomics and vaccine adverse event detection.  She is also involved in a whole genome data analysis project with the Inova Translational Medicine Institute.

Dr. Madhavan has a master of science in Information Technology from University of Maryland and a Ph.D. in Molecular Biology and Biological Sciences from the Uniformed Services University for the Health Sciences (Indo-US Collaborative program).

Select publications:

McGarvey P, Dharia S, Oberti M, Dragomir A, Hedlund E, Tanenbaum D, Suzek B, Madhavan S. “Informatics and Data Quality at Collaborative Multicenter Breast and Colon Cancer Family Registries”, JAMIA , Feb 10;10.1136. EPub. (2012).

Madhavan S, Gusev Y, Harris M, Tanenbaum DM, Gauba R, Bhuvaneshwar K, Shinohara A, Rosso K, Carabet L, Song L, Riggins RB, Dakshanamurthy S, Wang Y, Byers SW, Clarke R, Weiner LM. “G-DOC®: A Systems Medicine Platform for Personalized Oncology”, Neoplasia 13:9. (2011).

Madhavan S., Zenklusen J. C., Kotliarov Y., Sahni H., Fine H., and Buetow K. Rembrandt: Helping Personalized Medicine Become a Reality Through Integrative Translational Research. Molecular Cancer Research 7(2): 157-167. PMCID: PMC2645472. (2008).

Cancer Genome Atlas Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature455(7216):1061-8. PMCID: PMC2671642. (2008)

Madhavan S, Sander A, Chou W-Y, Shuster A, Boone K, Dente M, Shad A, Hesse B. “Pediatric Palliative Care in the Age of eHealth: Opportunities for Advances in HIT to Improve Patient-Centered Communication”, Am J Prev Medicine 40 (5) Supplement 2: S208 – S216. (2011)